Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

5.5.1.4

Official Name

inositol-3-phosphate synthase

Name from literature

l myo inositol phosphate synthase

Pathway from literature

conversion of D-glucose 6-phosphate to L-myo-inositol 1-phosphate in the inositol biosynthetic pathway

Pathway from KEGG

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521

Organisms

Yeast (4932)

Genome localization

-[853288 ],

Comments

Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.

Rate-limiting Description

"L-myo-inositol 1-phosphate synthase (EC 5.5.1.4; MIPS) catalyzes the first rate limiting conversion of D-glucose 6-phosphate to L-myo-inositol 1-phosphate in the inositol biosynthetic pathway." (16453101)

"L-myo-inositol 1-phosphate synthase (EC 5.5.1.4; MIPS) catalyzes conversion of glucose 6-phosphate to L-myo-inositol 1-phosphate, the first and the rate-limiting step in the production of inositol, and has been reported from evolutionarily diverse organisms." (14730448)

Regulatory Information

Upstream transcription factor

851415;851788;856891;851701;854042;854663;856856

Regulatory type

Detail

transcriptional factor;UME6(851788)

"The Isw2 chromatin remodeling complex represses early meiotic genes upon recruitment by Ume6p." (11081629)

transcriptional factor;SPT15(856891)

"Histone H3 phosphorylation can promote TBP recruitment through distinct promoter-specific mechanisms." (15719021)

transcriptional factor;INO2(851701)

"Mot1-mediated control of transcription complex assembly and activity." (15861138)

transcriptional factor;INO4(854042)

"Mot1-mediated control of transcription complex assembly and activity." (15861138)

transcriptional factor;RPO21(851415)

"Mot1-mediated control of transcription complex assembly and activity." (15861138)

transcriptional factor;SPT15(856891)

"Mot1-mediated control of transcription complex assembly and activity." (15861138)

transcriptional factor;SSL2(854663)

"An in vivo map of the yeast protein interactome." (18467557)

transcriptional factor;SCS2(856856)

"The Saccharomyces cerevisiae SCS2 gene product, a homolog of a synaptobrevin-associated protein, is an integral membrane protein of the endoplasmic reticulum and is required for inositol metabolism." (9537365)

Gene ontology

Gene ontology

GO:0008654 (P) phospholipid biosynthetic process [P11986 ];
GO:0004512 (F) inositol-3-phosphate synthase activity [P11986 ];
GO:0005737 (C) cytoplasm [P11986 ];
GO:0005515 (F) protein binding [P11986 ];
GO:0006021 (P) inositol biosynthetic process [P11986 ];

Subcellular localization

Localization

cytoplasm [P11986 ];

Links

SwissProt

P11986

Entrez Gene

853288



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  Last Modified: 2009-03-24  
  Design by Zhao Min