Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.21

Official Name

carnitine O-palmitoyltransferase

Name from literature

carnitine palmitoyltransferase 1a

Pathway from literature

fatty acid metabolism/fatty acid oxidation

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Cellular Processes; Endocrine System; Adipocytokine signaling pathway; map04920

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Organisms

Rat (10116)

Genome localization

5q35[25413 ], 1q43[25757 ], 7q34[25756 ],

Comments

Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.

Rate-limiting Description

"In contrast, phosphatidate phosphohydrolase, the rate-limiting enzyme for TG synthesis, was found to be 20% lower in the livers of the CLA-fed rats." (12359092)

Regulatory Information

Upstream transcription factor

81646;291567;25735;83516;25747

Regulatory type

Detail

phosphorylation;

P32198

phosphorylation;

Q63704

phosphorylation;

P32198:from_uniprot:588_Phosphothreonine

phosphorylation;

P32198:from_uniprot:604_Phosphothreonine

phosphorylation;

P32198:from_uniprot:741_Phosphoserine

phosphorylation;

P32198:from_uniprot:747_Phosphoserine

transcriptional factor;"CREB(81646),HNF4alpha(25735),PGC-1(83516)"

"Results show that CREB and HNF4alpha bind the CPT promoter, that PGC-1 is involved in liver carnitine palmitoyltransferase I (CPT) gene activation by cylic AMP, and that PGC-1 acts to coordinate the process of metabolic adaptation in the liver." (12107181)

transcriptional factor;PGC-1alpha(83516)

"peroxisomal proliferator-activated receptor-gamma coactivator-1(PGC-1)alpha participates in stimulation of Carnitine palmitoyltransferase I (CPT-I) alpha gene expression by thyroid hormone suggesting that PGC-1 alpha is a thyroid hormone coactivator" (15469941)

transcriptional factor;PPARalpha(25747)

"long-chain fatty acids regulate L-CPT I transcription through a PPARalpha-independent pathway, at least in hepatoma cells" (16177188#15254779)

transcriptional factor;PGC-1beta(291567)

"These results demonstrate that PGC-1beta is a coactivator in the T3 induction of CPT-Ialpha and that PGC-1beta has similarities and differences with the PGC-1alpha isoform" (17239528)

Gene ontology

Gene ontology

GO:0006810 (P) transport [Q63704, P32198, P18886 ];
GO:0004095 (F) carnitine O-palmitoyltransferase activity [Q63704, P32198, P18886 ];
GO:0006631 (P) fatty acid metabolic process [Q63704, P32198, P18886 ];
GO:0016021 (C) integral to membrane [Q63704, P32198 ];
GO:0005741 (C) mitochondrial outer membrane [Q63704, P32198 ];
GO:0005743 (C) mitochondrial inner membrane [P18886 ];

Subcellular localization

Localization

mitochondrion [Q63704, P32198, P18886 ];

membrane [P18886 ];

Links

SwissProt

P18886; P32198; Q63704

Entrez Gene

25413; 25756; 25757



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min