Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.21

Official Name

carnitine O-palmitoyltransferase

Name from literature

carnitine palmitoyltransferase 1a

Pathway from literature

fatty acid metabolism/fatty acid oxidation

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Cellular Processes; Endocrine System; Adipocytokine signaling pathway; map04920

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Organisms

Mouse (10090)

Genome localization

7 B2[78070 ], 15 E3|15 52.6 cM[12895 ], 4 C7|4 54.4 cM[12896 ], 19 A|19 2.0 cM[12894 ],

Comments

Broad specificity to acyl group, over the range C8 to C18; optimal activity with palmitoyl-CoA. cf. EC 2.3.1.7 carnitine O-acetyltransferase and EC 2.3.1.137 carnitine O-octanoyltransferase.

Rate-limiting Description

"To clarify the paradoxic effects of cerulenin, namely its in vitro inhibitory effects on fat catabolism and its in vivo reduction of fat mass, we studied the in vivo and in vitro effects of cerulenin on carnitine palmitoyltransferase-1 (CPT-1) activity, the rate-limiting enzyme of fatty acid oxidation." (15044358)

Regulatory Information

Upstream transcription factor

15378;12912;19013

Regulatory type

Detail

phosphorylation;

P97742

phosphorylation;

Q924X2

phosphorylation;

P97742:from_uniprot:588_Phosphothreonine

phosphorylation;

P97742:from_uniprot:604_Phosphothreonine

phosphorylation;

P97742:from_uniprot:741_Phosphoserine

phosphorylation;

P97742:from_uniprot:747_Phosphoserine

transcriptional factor;"CREB(12912),HNF4alpha(15378)"

"Results show that CREB and HNF4alpha bind the CPT promoter, that PGC-1 is involved in liver carnitine palmitoyltransferase I (CPT) gene activation by cylic AMP, and that PGC-1 acts to coordinate the process of metabolic adaptation in the liver." (12107181)

transcriptional factor;PPARalpha(19013)

"The PPARalpha targeted genes CPT-II and HMG-CoA synthase are potential regulators of mitochondrial fatty acid oxidation and ketogenesis in hTNFalpha transgenic mice, and the increased propionyl-CoA level found is a possible inhibitor of these processes. " (15893958)

Gene ontology

Gene ontology

GO:0006810 (P) transport [P52825 ];
GO:0004095 (F) carnitine O-palmitoyltransferase activity [Q924X2, P52825, P97742, Q8BGD5 ];
GO:0006631 (P) fatty acid metabolic process [Q924X2, P52825, P97742, Q8BGD5 ];
GO:0016021 (C) integral to membrane [Q924X2, P97742, Q8BGD5 ];
GO:0015909 (P) long-chain fatty acid transport [Q924X2 ];
GO:0005741 (C) mitochondrial outer membrane [Q924X2, P97742, Q8BGD5 ];
GO:0005743 (C) mitochondrial inner membrane [P52825, P97742 ];

Subcellular localization

Localization

mitochondrion [Q924X2, P52825, P97742, Q8BGD5 ];

membrane [P52825 ];

Links

SwissProt

P52825; P97742; Q8BGD5; Q924X2

Entrez Gene

12894; 12895; 12896; 78070



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min