Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.7.15

Official Name

choline-phosphate cytidylyltransferase

Name from literature

Choline-phosphate cytidylyltransferase

Pathway from literature

membrane phospholipid synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Aminophosphonate metabolism; map00440

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Rat (10116)

Genome localization

11q22[140544 ], Xq22[286936 ],

Rate-limiting Description

"The principle rate-limiting enzyme required for phosphatidylcholine production is cytidine 5'-triphosphate:cholinephosphate cytidylyltransferase." (8255685)

"This is consistent with the idea that the rate-limiting reaction is that catalyzed by cholinephosphate cytidylyltransferase." (7126613)

"These results indicate that cholinephosphate cytidylyltransferase catalyzes a rate-limiting reaction in phosphatidylcholine formation by fetal rat lung type II cells.." (6477961)

"Activity of cholinephosphate cytidylyltransferase, the rate-limiting enzyme in phosphatidylcholine synthesis, increases rapidly in the lung after birth predominantly due to an increase in membrane-associated activity." (9421188)

"The activity of CTP:cholinephosphate cytidylyltransferase (CPCT), the rate-limiting enzyme in phosphatidylcholine synthesis was reduced by approximately 50% by a 1:10 dilution of spore extract." (15574675)

"An analysis of the available data on the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine, by the logic derived from the theoretical principles of metabolic regulation, shows that the first two reactions catalysed by choline (ethanolamine) kinase and phosphocholine (phosphoethanolamine) cytidylyltransferase are rate-limiting, whereas the phosphocholine (phosphoethanolamine) transferase step is near equilibrium in rat liver.." (603639)

"The results confirm that CT has a rate-limiting and regulatory role in the synthesis of type II cell DSPC, and raise possibilities for novel therapeutic interventions." (10615073)

"The activities of the rate-limiting enzymes in the de novo synthesis of PC and PE, CTP:phosphocholine cytidylyltransferase (CT), and CTP:phosphoethanolamine cytidylyltransferase (ET), respectively, were measured in the retinas excised at 5:00, 9:00, 13:00, and 17:00 h from rats adapted to a 24-h cycle with lights on from 7:00 to 19:00 h." (11097182)

Regulatory Information

Upstream transcription factor

367846

Regulatory type

Detail

phosphorylation;

P19836

phosphorylation;

Q9QZC4

phosphorylation;

Q9QZC4:from_uniprot:233_Phosphoserine

phosphorylation;

Q9QZC4:from_uniprot:315_Phosphoserine

phosphorylation;

Q9QZC4:from_uniprot:319_Phosphoserine

phosphorylation;

Q9QZC4:from_uniprot:325_Phosphothreonine

transcriptional factor;Sp3(367846)

"the effect of Ha-Ras transformation on regulation of several forms of Sp3 as a downstream effector of a Ras/p42/44(MAPK) signaling pathway which increases CTP:phosphocholine cytidylyltransferase alpha gene transcription" (12584202)

Gene ontology

Gene ontology

GO:0008654 (P) phospholipid biosynthetic process [Q9QZC4 ];
GO:0005783 (C) endoplasmic reticulum [Q9QZC4 ];
GO:0004105 (F) choline-phosphate cytidylyltransferase acti... [Q9QZC4, P19836 ];

Subcellular localization

Localization

cell membrane [P19836 ];

endoplasmic reticulum [Q9QZC4 ];

cytoplasm [P19836 ];

Links

SwissProt

P19836; Q9QZC4

Entrez Gene

140544; 286936



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  Last Modified: 2009-03-24  
  Design by Zhao Min