Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.7.7.15

Official Name

choline-phosphate cytidylyltransferase

Name from literature

Choline-phosphate cytidylyltransferase

Pathway from literature

membrane phospholipid synthesis

Pathway from KEGG

Metabolism of Other Amino Acids; Aminophosphonate metabolism; map00440

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Mouse (10090)

Genome localization

X C3[236899 ], 16 B3|16 22.85 cM[13026 ],

Rate-limiting Description

"CTP:phosphocholine cytidylyltransferase (CCT) is the rate-limiting and regulated enzyme of mammalian phosphatidylcholine biosynthesis." (11279002)

"CTP:phosphocholine cytidylyltransferase (CT) is a rate-limiting and complexly regulated enzyme in phosphatidylcholine (PC) biosynthesis and is important in the adaptation of macrophages to cholesterol loading." (10101264)

Regulatory Information

Upstream transcription factor

21677;23871;20683

Regulatory type

Detail

phosphorylation;

P49586

phosphorylation;

P49586:from_uniprot:315_Phosphoserine

phosphorylation;

P49586:from_uniprot:319_Phosphoserine

phosphorylation;

P49586:from_uniprot:329_Phosphoserine

phosphorylation;

P49586:from_uniprot:331_Phosphoserine

phosphorylation;

P49586:from_uniprot:347_Phosphoserine

phosphorylation;

P49586:from_uniprot:362_Phosphoserine

phosphorylation;

Q811Q9:from_uniprot:233_Phosphoserine

phosphorylation;

Q811Q9:from_uniprot:315_Phosphoserine

phosphorylation;

Q811Q9:from_uniprot:319_Phosphoserine

phosphorylation;

Q811Q9:from_uniprot:325_Phosphothreonine

transcriptional factor;Sp1(20683)

"activation during the S phase of the cell cycle is mediated by the transcription factor Sp1" (12794070)

transcriptional factor;Sp1(20683)

"cyclin-dependent kinase 2 (CDK2) phosphorylation of Sp1 activates CTalpha transcription during S phase." (15247247)

transcriptional factor;Ets1(23871),TEF-4(21677)

"Identification of Ets-1 as an important transcriptional activator of CTP:phosphocholine cytidylyltransferase alpha in COS-7 cells and co-activation with transcriptional enhancer factor-4." (12642588)

phosphorylation;

"a physiologically relevant phosphorylation site and docking domain within CCTalpha serve as targets for ERKs, resulting in inhibition of surfactant synthesis" (15788406)

Gene ontology

Gene ontology

GO:0005783 (C) endoplasmic reticulum [Q811Q9 ];
GO:0001541 (P) ovarian follicle development [Q811Q9 ];
GO:0004105 (F) choline-phosphate cytidylyltransferase acti... [P49586, Q811Q9 ];
GO:0005789 (C) endoplasmic reticulum membrane [P49586 ];
GO:0008654 (P) phospholipid biosynthetic process [Q811Q9 ];
GO:0006656 (P) phosphatidylcholine biosynthetic process [P49586 ];
GO:0009628 (P) response to abiotic stimulus [P49586 ];
GO:0007283 (P) spermatogenesis [Q811Q9 ];
GO:0042587 (C) glycogen granule [P49586 ];

Subcellular localization

Localization

cell membrane [P49586 ];

endoplasmic reticulum [Q811Q9 ];

cytoplasm [P49586 ];

Links

SwissProt

P49586; Q811Q9

Entrez Gene

13026; 236899



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min