Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.99.5

Official Name

glycerol-3-phosphate dehydrogenase

Name from literature

glycerol phosphate dehydrogenase

Pathway from literature

glycerol phosphate shuttle

Pathway from KEGG

Lipid Metabolism; Glycerophospholipid metabolism; map00564

Organisms

Mouse (10090)

Genome localization

2 C1.1|2 33.0 cM[14571 ],

Rate-limiting Description

"Using the mice that lack mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), a rate limiting enzyme of the glycerol-phosphate NADH shuttle, we investigated the role of the NADH shuttle system in amylase secretion in response to acetylcholine (ACh) in pancreatic acinar cells." (12597242)

Regulatory Information

Regulatory type

Detail

phosphorylation;

Q64521

phosphorylation;

Q64521:from_uniprot:600_Phosphotyrosine

phosphorylation;

Q64521:from_uniprot:601_Phosphotyrosine

others;

"the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of prostate cancer" (17886033)

Gene ontology

Gene ontology

GO:0006072 (P) glycerol-3-phosphate metabolic process [Q64521 ];
GO:0006094 (P) gluconeogenesis [Q64521 ];
GO:0004368 (F) glycerol-3-phosphate dehydrogenase activity [Q64521 ];
GO:0009331 (C) glycerol-3-phosphate dehydrogenase complex [Q64521 ];
GO:0055114 (P) oxidation reduction [Q64521 ];
GO:0005743 (C) mitochondrial inner membrane [Q64521 ];
GO:0005509 (F) calcium ion binding [Q64521 ];

Subcellular localization

Localization

mitochondrion [Q64521 ];

Links

SwissProt

Q64521

Entrez Gene

14571



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  Last Modified: 2009-03-24  
  Design by Zhao Min