Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.18.2

Official Name

CMP-N-acetylneuraminate monooxygenase

Name from literature

CMP-N-acetylneuraminic acid hydroxylase

Pathway from literature

generating Neu5G c

Pathway from KEGG

Carbohydrate Metabolism; Aminosugars metabolism; map00530

Organisms

Rat (10116)

Genome localization

17p11[361245 ],

Comments

This enzyme contains both a Rieske-type [2Fe-2S] cluster and a second iron site. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). The enzyme can be activated by Fe2+ or Fe3+.

Rate-limiting Description

"From considerations of the effects of the structure of the lactosylceramide molecular species on the Vmax and Km for CMP-N-acetylneuraminic acid, it is likely that LacCer alpha 2,3-ST first binds lactosylceramide and then CMP-N-acetylneuraminic acid and that the rate-limiting step in the reaction is the release of the product GM3." (8195125)

Links

Entrez Gene

361245



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  Last Modified: 2009-03-24  
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