Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.18.2

Official Name

CMP-N-acetylneuraminate monooxygenase

Name from literature

CMP-N-acetylneuraminic acid hydroxylase

Pathway from literature

generating Neu5G c

Pathway from KEGG

Carbohydrate Metabolism; Aminosugars metabolism; map00530

Organisms

Mouse (10090)

Genome localization

13 A3.2[12763 ],

Comments

This enzyme contains both a Rieske-type [2Fe-2S] cluster and a second iron site. The ferricytochrome b5 produced is reduced by NADH and cytochrome-b5 reductase (EC 1.6.2.2). The enzyme can be activated by Fe2+ or Fe3+.

Rate-limiting Description

"The molecular activity of the enzyme (approximately 500/min) is much lower than that reported for NADH-cytochrome b5 reductase, suggesting that the activity or amount of hydroxylase is rate-limiting in CMP-N-glycolylneuraminic acid (NeuGc) biosynthesis." (8132639)

Gene ontology

Gene ontology

GO:0051537 (F) 2 iron, 2 sulfur cluster binding [Q61419 ];
GO:0005783 (C) endoplasmic reticulum [Q61419 ];
GO:0030338 (F) CMP-N-acetylneuraminate monooxygenase activity [Q61419 ];
GO:0022900 (P) electron transport chain [Q61419 ];
GO:0005506 (F) iron ion binding [Q61419 ];
GO:0006810 (P) transport [Q61419 ];
GO:0009055 (F) electron carrier activity [Q61419 ];
GO:0046381 (P) CMP-N-acetylneuraminate metabolic process [Q61419 ];

Subcellular localization

Localization

endoplasmic reticulum [Q61419 ];

cytoplasm [Q61419 ];

Links

SwissProt

Q61419

Entrez Gene

12763



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  Last Modified: 2009-03-24  
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