Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.2.13

Official Name

fructose-bisphosphate aldolase

Name from literature

aldolase

Pathway from literature

glycolysis

Pathway from KEGG

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Pentose phosphate pathway; map00030

Carbohydrate Metabolism; Glycolysis / Gluconeogenesis; map00010

Energy Metabolism; Carbon fixation; map00710

Organisms

Rat (10116)

Genome localization

5q22[24190 ], 1q36[24189 ], -[24191 ],

Comments

Also acts on (3S,4R)-ketose 1-phosphates. The yeast and bacterial enzymes are zinc proteins. The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc.

Rate-limiting Description

"These studies are consistent with the aldolase-catalyzed cleavage of fructose 1-phosphate being rate-limiting in hepatic fructose metabolism, and that the CCl4 and BB treatment modify and inactivate the aldolase enzyme." (8015399)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P00884:from_uniprot:36_Phosphoserine

phosphorylation;

P09117:from_uniprot:119_Phosphothreonine

phosphorylation;

P09117:from_uniprot:39_Phosphoserine

Gene ontology

Gene ontology

GO:0004332 (F) fructose-bisphosphate aldolase activity [P05065, P00884, Q6PCU3, Q6AY07, P09117 ];
GO:0006094 (P) gluconeogenesis [Q66HT1 ];
GO:0006096 (P) glycolysis [P05065, P00884, Q6PCU3, Q6AY07, P09117 ];
GO:0042594 (P) response to starvation [Q66HT1 ];
GO:0043434 (P) response to peptide hormone stimulus [Q66HT1 ];
GO:0005829 (C) cytosol [Q66HT1 ];
GO:0051384 (P) response to glucocorticoid stimulus [Q66HT1 ];
GO:0046688 (P) response to copper ion [Q66HT1 ];
GO:0009743 (P) response to carbohydrate stimulus [Q66HT1 ];
GO:0048471 (C) perinuclear region of cytoplasm [Q66HT1 ];
GO:0005634 (C) nucleus [Q66HT1 ];
GO:0005764 (C) lysosome [Q66HT1 ];
GO:0010043 (P) response to zinc ion [Q66HT1 ];

Links

SwissProt

P00884; P05065; P09117; Q66HT1; Q6AY07; Q6PCU3

Entrez Gene

24189; 24190; 24191



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min