Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.205

Official Name

IMP dehydrogenase

Name from literature

Inosine monophosphate dehydrogenase

Pathway from literature

the de novo synthesis of guanine nucleotides from IMP

Pathway from KEGG

Nucleotide Metabolism; Purine metabolism; map00230

Xenobiotics Biodegradation and Metabolism; Drug metabolism - other enzymes; map00983

Organisms

Mouse (10090)

Genome localization

9 F2[23918 ], 6 A3[23917 ],

Comments

The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.

Rate-limiting Description

"IMPDH1 is a highly conserved, widely expressed housekeeping gene, the product of which catalyzes the rate-limiting step of de novo guanine synthesis." (16936083)

"IMPDH1 is a ubiquitously expressed enzyme, functioning as a homotetramer, which catalyzed the rate-limiting step in de novo synthesis of guanine nucleotides." (11875050)

"Inosine 5'-monophosphate dehydrogenase (IMPDH) is the critical, rate-limiting enzyme in the de novo biosynthesis pathway for guanine nucleotides." (12944494)

"Inosine 5'-monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in the de novo synthesis of guanine nucleotides, which are also synthesized from guanine by a salvage reaction catalyzed by the X chromosome-linked enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT)." (10953035)

"Inosine 5'-monophosphate dehydrogenase (IMPDH) enzyme catalyzes the rate-limiting step in the de novo biosynthesis of guanine nucleotides." (12183689)

Regulatory Information

Upstream transcription factor

17869

Regulatory type

Detail

phosphorylation;

P24547

phosphorylation;

P24547:from_uniprot:400_Phosphotyrosine

transcriptional factor;c-myc(17869)

"To determine the functional significance of c-Myc regulation of nucleotide metabolism, we sought to determine the effect of loss of function of direct Myc targets inosine monophosphate dehydrogenases (IMPDH1 and IMPDH2) on c-Myc-induced cell growth and proliferation. " (18628958)

Gene ontology

Gene ontology

GO:0046651 (P) lymphocyte proliferation [P24547, P50096 ];
GO:0006177 (P) GMP biosynthetic process [P24547, P50096 ];
GO:0030955 (F) potassium ion binding [P24547, P50096 ];
GO:0003938 (F) IMP dehydrogenase activity [P24547, P50096 ];
GO:0055114 (P) oxidation reduction [P24547, P50096 ];

Links

SwissProt

P24547; P50096

Entrez Gene

23917; 23918



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  Last Modified: 2009-03-24  
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