Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.3.1.20

Official Name

diacylglycerol O-acyltransferase

Name from literature

diacylglycerol acyltransferase

Pathway from literature

diacylglycerol conversion to triacylglycerol

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830

Organisms

Mouse (10090)

Genome localization

7 F1[67800 ], 15 D3|15 46.9 cM[13350 ],

Comments

Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.

Rate-limiting Description

"Acyl-CoA:monoacylglycerol acyltransferase (MGAT) plays an important role in dietary fat absorption by catalyzing a rate-limiting step in the re-synthesis of diacylglycerols in enterocytes." (12730219)

Regulatory Information

Upstream transcription factor

12606;12608

Regulatory type

Detail

phosphorylation;

Q9Z2A7:from_uniprot:20_Phosphoserine

transcriptional factor;"C/EBPbeta(12608),C/EBPalpha(12606)"

"diacylglycerol acyltransferase 2 expression is regulated by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis" (17504763)

Gene ontology

Gene ontology

GO:0006071 (P) glycerol metabolic process [Q9DCV3 ];
GO:0005624 (C) membrane fraction [Q9DCV3 ];
GO:0016021 (C) integral to membrane [Q9DCV3, Q9Z2A7 ];
GO:0019432 (P) triacylglycerol biosynthetic process [Q9DCV3 ];
GO:0004144 (F) diacylglycerol O-acyltransferase activity [Q9DCV3, Q9Z2A7 ];
GO:0003846 (F) 2-acylglycerol O-acyltransferase activity [Q9DCV3, Q9Z2A7 ];
GO:0005789 (C) endoplasmic reticulum membrane [Q9DCV3, Q9Z2A7 ];

Subcellular localization

Localization

endoplasmic reticulum [Q9DCV3, Q9Z2A7 ];

Links

SwissProt

Q9DCV3; Q9Z2A7

Entrez Gene

13350; 67800



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min