Rate-Limiting Enzyme

Basic Information
Enzyme Number	2.3.1.20
Official Name	diacylglycerol O-acyltransferase
Name from literature	diacylglycerol acyltransferase
Pathway from literature	diacylglycerol conversion to triacylglycerol
Pathway from KEGG	Lipid Metabolism; Glycerolipid metabolism; map00561
	Metabolism of Cofactors and Vitamins; Retinol metabolism; map00830
Organisms	Mouse (10090)
Genome localization	7 F1[67800 ], 15 D3\|15 46.9 cM[13350 ],
Comments	Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
Rate-limiting Description	"Acyl-CoA:monoacylglycerol acyltransferase (MGAT) plays an important role in dietary fat absorption by catalyzing a rate-limiting step in the re-synthesis of diacylglycerols in enterocytes." (12730219)
Regulatory Information
Upstream transcription factor	12606;12608
Regulatory type	Detail
phosphorylation;	Q9Z2A7:from_uniprot:20_Phosphoserine
transcriptional factor;"C/EBPbeta(12608),C/EBPalpha(12606)"	"diacylglycerol acyltransferase 2 expression is regulated by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis" (17504763)
Gene ontology
Gene ontology	GO:0006071 (P) glycerol metabolic process [Q9DCV3 ]; GO:0005624 (C) membrane fraction [Q9DCV3 ]; GO:0016021 (C) integral to membrane [Q9DCV3, Q9Z2A7 ]; GO:0019432 (P) triacylglycerol biosynthetic process [Q9DCV3 ]; GO:0004144 (F) diacylglycerol O-acyltransferase activity [Q9DCV3, Q9Z2A7 ]; GO:0003846 (F) 2-acylglycerol O-acyltransferase activity [Q9DCV3, Q9Z2A7 ]; GO:0005789 (C) endoplasmic reticulum membrane [Q9DCV3, Q9Z2A7 ];
Subcellular localization
Localization	endoplasmic reticulum [Q9DCV3, Q9Z2A7 ];
Links
SwissProt	Q9DCV3; Q9Z2A7
Entrez Gene	13350; 67800

	Copyright 2009, Center for Bioinformatics
	Last Modified: 2009-03-24
	Design by Zhao Min