Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

3.4.23.46

Official Name

memapsin 2

Name from literature

Beta-site APP cleaving enzyme

Pathway from literature

beta amyloid production

Pathway from KEGG

Human Diseases; Neurodegenerative Diseases; Alzheimer's disease; map05010

Organisms

Rat (10116)

Genome localization

8q22[29392 ],

Comments

Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain.

Rate-limiting Description

"Consequently, inhibition of BACE-1, a rate-limiting enzyme in the production of Abeta, is an attractive therapeutic approach for the treatment of AD." (18295609)

"Beta-site APP cleaving enzyme-1 (BACE-1), is a rate-limiting enzyme for beta amyloid production." (18695518)

Regulatory Information

Upstream transcription factor

81736

Regulatory type

Detail

transcriptional factor;NFkappaB(81736)

"wild-type or Swedish mutated betaAPP overexpression modulates BACE1 promoter transactivation and activity via an NFkappaB-dependent pathway." (18263584)

Gene ontology

Gene ontology

GO:0050435 (P) beta-amyloid metabolic process [P56819 ];
GO:0016021 (C) integral to membrane [P56819 ];
GO:0006508 (P) proteolysis [P56819 ];
GO:0005768 (C) endosome [P56819 ];
GO:0005794 (C) Golgi apparatus [P56819 ];
GO:0004190 (F) aspartic-type endopeptidase activity [P56819 ];

Subcellular localization

Localization

cell membrane [P56819 ];

Links

SwissProt

P56819

Entrez Gene

29392



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  Last Modified: 2009-03-24  
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