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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 3.4.23.46 |
Official Name | memapsin 2 |
Name from literature | Beta-site APP cleaving enzyme |
Pathway from literature | beta amyloid production |
Pathway from KEGG |
Human Diseases; Neurodegenerative Diseases; Alzheimer's disease; map05010 |
Organisms | Rat (10116) |
Genome localization | 8q22[29392 ], |
Comments | Suggested to be the major "beta-secretase" responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. In peptidase family A1 but is atypical in containing a C-terminal membrane-spanning domain. |
Rate-limiting Description | "Consequently, inhibition of BACE-1, a rate-limiting enzyme in the production of Abeta, is an attractive therapeutic approach for the treatment of AD." (18295609) |
| "Beta-site APP cleaving enzyme-1 (BACE-1), is a rate-limiting enzyme for beta amyloid production." (18695518) |
Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
transcriptional factor;NFkappaB(81736) | "wild-type or Swedish mutated betaAPP overexpression modulates BACE1 promoter transactivation and activity via an NFkappaB-dependent pathway." (18263584) |
Gene ontology |
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Gene ontology |
GO:0050435 (P) beta-amyloid metabolic process [P56819 ]; |
Subcellular localization |
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Localization |
cell membrane [P56819 ]; |
Links |
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SwissProt | |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |