Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.13.11.11

Official Name

tryptophan 2,3-dioxygenase

Name from literature

tryptophan 2,3-dioxygenase

Pathway from literature

kynurenine pathway/tryptophan catabolism

Pathway from KEGG

Amino Acid Metabolism; Tryptophan metabolism; map00380

Organisms

Mouse (10090)

Genome localization

3 E3[56720 ],

Comments

A protohemoprotein. In mammals, the enzyme appears to be located only in the liver. This enzyme, together with EC 1.13.11.52, indoleamine 2,3-dioxygenase, catalyses the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism [5]. The enzyme is specific for tryptophan as substrate, but is far more active with L-tryptophan than with D-tryptophan [2].

Rate-limiting Description

"Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the L-tryptophan-kynurenine pathway, which converts an essential amino acid, L-tryptophan, to N-formylkynurenine." (11477543)

"This enzyme is inducible by cytokines such as interferon-gamma (IFN-gamma) and is the first and rate-limiting enzyme of the catabolism pathway of tryptophan." (12401474)

Regulatory Information

Regulatory type

Detail

phosphorylation;

P48776

phosphorylation;

P48776:from_uniprot:155_Phosphoserine

phosphorylation;

P48776:from_uniprot:19_Phosphoserine

transcriptional level;TNF alpha(21926),IFN-gamma

"The present study used IFN-gamma or TNF-alpha gene-disrupted mice and IFN-gamma antibody-treated mice to demonstrate that lipopolysaccharide (LPS)-induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma. IFN-gamma-independent IDO induction was also demonstrated in vitro with LPS-stimulated monocytic THP-1 cells. These findings clearly indicate that there is an IFN-gamma-independent mechanism of IDO induction in addition to the IFN-gamma-dependent mechanism." (11477543)

Gene ontology

Gene ontology

GO:0019441 (P) tryptophan catabolic process to kynurenine [P48776 ];
GO:0055114 (P) oxidation reduction [P48776 ];
GO:0005506 (F) iron ion binding [P48776 ];
GO:0004833 (F) tryptophan 2, 3-dioxygenase activity [P48776 ];

Links

SwissProt

P48776

Entrez Gene

56720



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  Last Modified: 2009-03-24  
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