Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

4.1.1.29

Official Name

sulfinoalanine decarboxylase

Name from literature

sulfoalanine decarboxylase

Pathway from literature

the biosynthesis of taurine

Pathway from KEGG

Metabolism of Other Amino Acids; Taurine and hypotaurine metabolism; map00430

Organisms

Mouse (10090)

Genome localization

-[246277 ],

Comments

A pyridoxal-phosphate protein. Also acts on L-cysteate. The 1992 edition of the Enzyme List erroneously gave the name sulfoalanine decarboxylase to this enzyme.

Rate-limiting Description

"Cysteine sulfinate decarboxylase (CSD) is the rate-limiting biosynthetic enzyme of taurine, but it is still controversial whether the male reproductive organs have the function to synthesize taurine through CSD pathway." (16252094)

"Cysteine sulfinic acid decarboxylase (CSD) is the rate-limiting enzyme for biosynthesis of taurine which is essential to biological processes such as development of the brain and eye, reproduction, osmoregulation as well as the anti-inflammatory activity of leukocytes." (11997111)

"Cysteine sulfinic acid decarboxylase, a rate-limiting enzyme for taurine biosynthesis, has been cloned and sequenced in the mouse, rat and human." (14553911)

Gene ontology

Gene ontology

GO:0004782 (F) sulfinoalanine decarboxylase activity [Q9DBE0 ];
GO:0030170 (F) pyridoxal phosphate binding [Q9DBE0 ];
GO:0019452 (P) L-cysteine catabolic process to taurine [Q9DBE0 ];

Links

SwissProt

Q9DBE0

Entrez Gene

246277



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  Last Modified: 2009-03-24  
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