Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

Official Name

inositol-3-phosphate synthase

Name from literature

l myo inositol phosphate synthase

Pathway from literature

inositol biosynthesis

Pathway from KEGG

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521


Rat (10116)


Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.

Rate-limiting Description

"CONCLUSIONS: The rate-limiting step of inositol biosynthesis, catalyzed by MIP synthase, is inhibited by VPA; inositol depletion is a first event shown to be common to lithium and VPA." (15576064)

Gene ontology

Gene ontology

GO:0008654 (P) phospholipid biosynthetic process [Q6AYK3 ];
GO:0004512 (F) inositol-3-phosphate synthase activity [Q6AYK3 ];
GO:0005488 (F) binding [Q6AYK3 ];
GO:0005737 (C) cytoplasm [Q6AYK3 ];
GO:0006021 (P) inositol biosynthetic process [Q6AYK3 ];

Subcellular localization


cytoplasm [Q6AYK3 ];




  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min