Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

5.5.1.4

Official Name

inositol-3-phosphate synthase

Name from literature

l myo inositol phosphate synthase

Pathway from literature

inositol biosynthesis

Pathway from KEGG

Carbohydrate Metabolism; Inositol phosphate metabolism; map00562

Biosynthesis of Secondary Metabolites; Streptomycin biosynthesis; map00521

Organisms

Mouse (10090)

Comments

Requires NAD+, which dehydrogenates the -CHOH- group to -CO- at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the -CHO at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the -CHOH- form.

Rate-limiting Description

"CONCLUSIONS: The rate-limiting step of inositol biosynthesis, catalyzed by MIP synthase, is inhibited by VPA; inositol depletion is a first event shown to be common to lithium and VPA." (15576064)

Gene ontology

Gene ontology

GO:0008654 (P) phospholipid biosynthetic process [Q9JHU9 ];
GO:0004512 (F) inositol-3-phosphate synthase activity [Q9JHU9 ];
GO:0005488 (F) binding [Q9JHU9 ];
GO:0005737 (C) cytoplasm [Q9JHU9 ];
GO:0006021 (P) inositol biosynthetic process [Q9JHU9 ];

Subcellular localization

Localization

cytoplasm [Q9JHU9 ];

Links

SwissProt

Q9JHU9



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  Last Modified: 2009-03-24  
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