Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.2.1.3

Official Name

long-chain-fatty-acid---CoA ligase

Name from literature

arachidonyl coA synthetase

Pathway from literature

fatty acid internalization

Pathway from KEGG

Lipid Metabolism; Fatty acid metabolism; map00071

Cellular Processes; Endocrine System; Adipocytokine signaling pathway; map04920

Cellular Processes; Endocrine System; PPAR signaling pathway; map03320

Organisms

Mouse (10090)

Genome localization

8 B2[14081 ], X F2[50790 ], 11 B1.3|11 29.35 cM[216739 ], 1 C4|1 24.1 cM[74205 ], 19 D2[433256 ],

Comments

Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24.

Rate-limiting Description

"Taken together, these results support the hypotheses that ACSs are rate-limiting for fatty acid internalization and that ACS2 enhances neurite outgrowth by promoting PUFA internalization." (15051725)

Regulatory Information

Upstream transcription factor

20787

Regulatory type

Detail

phosphorylation;

O35488

phosphorylation;

P41216

phosphorylation;

Q99PU5

phosphorylation;

Q9CZW4

phosphorylation;

Q9QUJ7

phosphorylation;

P41216:from_uniprot:85_Phosphotyrosine

phosphorylation;

Q99PU5:from_uniprot:132_Phosphotyrosine

phosphorylation;

Q99PU5:from_uniprot:135_Phosphotyrosine

phosphorylation;

Q99PU5:from_uniprot:136_Phosphotyrosine

phosphorylation;

Q99PU5:from_uniprot:655_Phosphotyrosine

phosphorylation;

Q9CZW4:from_uniprot:593_Phosphoserine

transcriptional factor;SREBP-1c(20787)

"Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins." (11567032)

Gene ontology

Gene ontology

GO:0000287 (F) magnesium ion binding [Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];
GO:0007405 (P) neuroblast proliferation [Q91WC3 ];
GO:0016020 (C) membrane [Q2XU92 ];
GO:0007275 (P) multicellular organismal development [Q2XU92 ];
GO:0005829 (C) cytosol [Q2XU92 ];
GO:0030154 (P) cell differentiation [Q2XU92 ];
GO:0016021 (C) integral to membrane [O35488, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];
GO:0005515 (F) protein binding [Q91WC3 ];
GO:0005743 (C) mitochondrial inner membrane [Q8JZR0 ];
GO:0007283 (P) spermatogenesis [Q2XU92 ];
GO:0005783 (C) endoplasmic reticulum [Q99PU5 ];
GO:0006635 (P) fatty acid beta-oxidation [Q2XU92 ];
GO:0005739 (C) mitochondrion [O35488 ];
GO:0005778 (C) peroxisomal membrane [O35488, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];
GO:0031410 (C) cytoplasmic vesicle [Q99PU5 ];
GO:0004467 (F) long-chain-fatty-acid-CoA ligase activity [O35488, Q8JZR0, Q9CZW4, Q9QUJ7, Q2XU92, Q99PU5, Q91WC3, P41216 ];
GO:0005789 (C) endoplasmic reticulum membrane [O35488, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];
GO:0001676 (P) long-chain fatty acid metabolic process [O35488, Q99PU5 ];
GO:0006631 (P) fatty acid metabolic process [Q8JZR0, Q9CZW4, Q91WC3, P41216 ];
GO:0019217 (P) regulation of fatty acid metabolic process [Q9QUJ7 ];
GO:0005792 (C) microsome [Q2XU92, Q99PU5, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];
GO:0031957 (F) very-long-chain-fatty-acid-CoA ligase activity [Q99PU5 ];
GO:0000038 (P) very-long-chain fatty acid metabolic process [Q99PU5 ];
GO:0005741 (C) mitochondrial outer membrane [Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];

Subcellular localization

Localization

cell membrane [Q2XU92 ];

mitochondrion [Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];

endoplasmic reticulum [O35488, Q99PU5, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];

peroxisome [O35488, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];

microsome [Q99PU5, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];

membrane [O35488, Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ];

cytoplasm [Q2XU92, Q99PU5 ];

Links

SwissProt

O35488; P41216; Q2XU92; Q8JZR0; Q91WC3; Q99PU5; Q9CZW4; Q9QUJ7

Entrez Gene

14081; 216739; 433256; 50790; 74205



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min