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Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases |
Basic Information |
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Enzyme Number | 6.2.1.3 |
Official Name | long-chain-fatty-acid---CoA ligase |
Name from literature | arachidonyl coA synthetase |
Pathway from literature | fatty acid internalization |
Pathway from KEGG |
Lipid Metabolism; Fatty acid metabolism; map00071 |
Cellular Processes; Endocrine System; Adipocytokine signaling pathway; map04920 | |
Cellular Processes; Endocrine System; PPAR signaling pathway; map03320 | |
Organisms | Mouse (10090) |
Genome localization | 8 B2[14081 ], X F2[50790 ], 11 B1.3|11 29.35 cM[216739 ], 1 C4|1 24.1 cM[74205 ], 19 D2[433256 ], |
Comments | Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. The liver enzyme acts on acids from C6 to C20; that from brain shows high activity up to C24. |
Rate-limiting Description | "Taken together, these results support the hypotheses that ACSs are rate-limiting for fatty acid internalization and that ACS2 enhances neurite outgrowth by promoting PUFA internalization." (15051725) |
Regulatory Information |
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Upstream transcription factor | |
Regulatory type | Detail |
phosphorylation; | O35488 |
phosphorylation; | P41216 |
phosphorylation; | Q99PU5 |
phosphorylation; | Q9CZW4 |
phosphorylation; | Q9QUJ7 |
phosphorylation; | P41216:from_uniprot:85_Phosphotyrosine |
phosphorylation; | Q99PU5:from_uniprot:132_Phosphotyrosine |
phosphorylation; | Q99PU5:from_uniprot:135_Phosphotyrosine |
phosphorylation; | Q99PU5:from_uniprot:136_Phosphotyrosine |
phosphorylation; | Q99PU5:from_uniprot:655_Phosphotyrosine |
phosphorylation; | Q9CZW4:from_uniprot:593_Phosphoserine |
transcriptional factor;SREBP-1c(20787) | "Identification of a mammalian long chain fatty acyl elongase regulated by sterol regulatory element-binding proteins." (11567032) |
Gene ontology |
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Gene ontology |
GO:0000287 (F) magnesium ion binding [Q8JZR0, Q9CZW4, Q9QUJ7, Q91WC3, P41216 ]; |
Subcellular localization |
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Localization |
cell membrane [Q2XU92 ]; |
Links |
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SwissProt | O35488; P41216; Q2XU92; Q8JZR0; Q91WC3; Q99PU5; Q9CZW4; Q9QUJ7 |
Entrez Gene |
Copyright 2009, Center for Bioinformatics | |||
Last Modified: 2009-03-24 | |||
Design by Zhao Min |