Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

6.3.4.16

Official Name

carbamoyl-phosphate synthase (ammonia)

Name from literature

carbamyl phosphate synthetase

Pathway from literature

urea cycle/urea production

Pathway from KEGG

Amino Acid Metabolism; Urea cycle and metabolism of amino groups; map00220

Amino Acid Metabolism; Glutamate metabolism; map00251

Amino Acid Metabolism; Arginine and proline metabolism; map00330

Energy Metabolism; Nitrogen metabolism; map00910

Organisms

Rat (10116)

Genome localization

9q32[497840 ],

Rate-limiting Description

"15-20% of mitochondrial matrix protein, is involved in the entry and rate-limiting step of the urea cycle." (1828177)

"Ornithine prevented the increase in both normal and hepatectomized rats, suggesting that ornithine was rate limiting for the ornithine carbamoyltransferase (OCT) reaction." (3993779)

Regulatory Information

Upstream transcription factor

25301

Regulatory type

Detail

phosphorylation;

P07756:from_uniprot:898_Phosphoserine

transcriptional factor;C/EBP(25301),HNF3

"Glucocorticoid receptor, C/EBP, HNF3, and protein kinase A coordinately activate the glucocorticoid response unit of the carbamoylphosphate synthetase I gene." (9774647)

Gene ontology

Gene ontology

GO:0006541 (P) glutamine metabolic process [P07756 ];
GO:0005739 (C) mitochondrion [P07756 ];
GO:0000050 (P) urea cycle [P07756 ];
GO:0004087 (F) carbamoyl-phosphate synthase (ammonia) acti... [P07756 ];
GO:0005524 (F) ATP binding [P07756 ];

Subcellular localization

Localization

mitochondrion [P07756 ];

Links

SwissProt

P07756

Entrez Gene

497840



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  Last Modified: 2009-03-24  
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