Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.19.3

Official Name

linoleoyl-CoA desaturase

Name from literature

Delta6 desaturase (D6D)

Pathway from literature

highly unsaturated fatty acid (HUFA) synthesis

Pathway from KEGG

Lipid Metabolism; Linoleic acid metabolism; map00591

Organisms

Rat (10116)

Comments

An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase.

Rate-limiting Description

"Delta6 desaturase (D6D), the rate-limiting enzyme for highly unsaturated fatty acid (HUFA) synthesis, is induced by essential fatty acid-deficient diets." (16106047)

Regulatory Information

Upstream transcription factor

20787;19013

Regulatory type

Detail

transcriptional factor;SREBP-1c(20787),PPARalpha(19013)

"Delta6 desaturase (D6D), the rate-limiting enzyme for highly unsaturated fatty acid (HUFA) synthesis, is induced by essential fatty acid-deficient diets. Sterol regulatory element-binding protein-1c (SREBP-1c) in part mediates this induction.Delta6 desaturase (D6D), the rate-limiting enzyme for highly unsaturated fatty acid (HUFA) synthesis, is induced by essential fatty acid-deficient diets. Sterol regulatory element-binding protein-1c (SREBP-1c) in part mediates this induction." (16106047)

transcriptional factor;"CAAT,Sp1,NF1 family"

"There is no sequence homology between the two promoters but they are both TATA-less, have conserved CAAT boxes at a matching distance (-85/-70 bp) from the transcription start site and contain cis-elements for transcription factors of the CAAT, Sp1 and NF1 family, all in accordance with ubiquitous expression of both genes. " (14697519)

Links



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min