Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.14.19.3

Official Name

linoleoyl-CoA desaturase

Name from literature

Delta6 desaturase (D6D)

Pathway from literature

highly unsaturated fatty acid (HUFA) synthesis

Pathway from KEGG

Lipid Metabolism; Linoleic acid metabolism; map00591

Organisms

Human (9606)

Comments

An iron protein. The rat liver enzyme is an enzyme system involving cytochrome b5 and EC 1.6.2.2, cytochrome-b5 reductase.

Rate-limiting Description

"Delta-6 desaturase (D6D) catalyzes the first and rate-limiting step of the HUFA synthesis." (12538078)

Regulatory Information

Upstream transcription factor

6720

Regulatory type

Detail

transcriptional factor;SREBP-1c(6720)

"Recent identification of a human case of D6D deficiency underscores the importance of this pathway. Sterol regulatory element binding protein-1c (SREBP-1c) is a key transcription factor that activates transcription of genes involved with fatty acid synthesis. We recently identified sterol regulatory element (SRE) that is required for activation of the human D6D gene by SREBP-1c." (12538078)

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  Last Modified: 2009-03-24  
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