Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

1.1.1.21

Official Name

aldehyde reductase

Name from literature

aldose reductase

Pathway from literature

the polyol pathway

Pathway from KEGG

Lipid Metabolism; Glycerolipid metabolism; map00561

Carbohydrate Metabolism; Pyruvate metabolism; map00620

Carbohydrate Metabolism; Fructose and mannose metabolism; map00051

Carbohydrate Metabolism; Pentose and glucuronate interconversions; map00040

Carbohydrate Metabolism; Galactose metabolism; map00052

Organisms

Rat (10116)

Genome localization

4q22[24192 ],

Comments

Has wide specificity.

Rate-limiting Description

"Although aldose reductase (AR), the rate-limiting enzyme in this pathway, is a target for pharmacological intervention of diabetic complications, the clinical efficacy of AR inhibitors has not been consistently proved." (10727516)

Regulatory Information

Upstream transcription factor

20683;26423;12608

Regulatory type

Detail

transcriptional factor;SF-1 (26423),C/EBPbeta (12608),ubiquitous transcription factors NF1,Sp1(20683)

"SF-1 (steroidogenic factor-1), C/EBPbeta (CCAAT/enhancer binding protein), and ubiquitous transcription factors NF1 (nuclear factor 1) and Sp1 (selective promoter factor 1) are required for regulation of the mouse aldose reductase-like gene (AKR1B7) expression in adrenocortical cells." (11145742)

transcriptional level;

"Nitric oxide up-regulates aldose reductase expression in rat vascular smooth muscle cells: a potential role for aldose reductase in vascular remodeling." (10727516)

;

P07943:from_uniprot:23_Phosphoserine

;

P07943:from_uniprot:40_Phosphotyrosine

Gene ontology

Gene ontology

GO:0055114 (P) oxidation reduction [P07943 ];
GO:0005737 (C) cytoplasm [P07943 ];
GO:0004032 (F) aldehyde reductase activity [P07943 ];

Subcellular localization

Localization

cytoplasm [P07943 ];

Links

SwissProt

P07943

Entrez Gene

24192



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  Last Modified: 2009-03-24  
  Design by Zhao Min