Center for Bioinformatics
Oxidoreductases | Transferases | Hydrolases | Lyases | Isomerases | Ligases

Basic Information

Enzyme Number

2.6.1.16

RLRdb entry

RL00275

Organisms

Homo sapiens (Human) (9606_human)

Synonyms

Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2;
EC=2.6.1.16;
Glutamine:fructose 6 phosphate amidotransferase 2;
Short=GFAT 2;
Short=GFAT2;
D-fructose-6-phosphate amidotransferase 2;
Hexosephosphate aminotransferase 2;

Key words

Aminotransferase, Glutamine amidotransferase, Phosphoprotein, Polymorphism, Repeat, Transferase

Links to iHOP

O94808

Function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.

Catalytic activity

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate

Gene ontology

P:energy reserve metabolic process
P:fructose 6-phosphate metabolic process
F:glutamine-fructose-6-phosphate transaminase...
C:cytoplasm
P:carbohydrate biosynthetic process
F:sugar binding
P:glutamine metabolic process

Tissue specificity

Highest levels of expression in heart, placenta, and spinal cord.

Fasta

>O94808 : length: 682
MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKR
GKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHN
GIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEG
AFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMK
RLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSAS
DDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDH
LKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFF
ISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYT
SQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRS
LLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCF
AKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFH
LAVLRGYDVDFPRNLAKSVTVE



  Copyright 2009, Center for Bioinformatics 
  Last Modified: 2009-03-24  
  Design by Zhao Min